Clindamycin and Trimethoprim-Sulfamethoxazole Equally Effective for Wound Infections

A large, high-quality trial finds that 92% of wound infections are cured with either antibiotic. Some observational studies have raised concerns about the potential inferiority of trimethoprim-sulfamethoxazole (TMP-SMX) to clindamycin for treatment of wound infections. To compare the two medications, investigators conducted a multi center  randomized, double-blind, placebo-controlled trial of 7-day courses of clindamycin (300 mg 4 times daily) versus TMP-SMX (320/1600 mg twice daily) in 500 emergency department patients older than 12 years with uncomplicated wound infections. Read more.